Air filters are able to remove certain pollutants from the air but are not a substitute for fresh air ventilation. Many pollutants are gasous and are not removed by particulate filters. Many gasous pollutants can be removed by using activated charcoal/potasium premangenate filters but must be replace periodically.
The majority of the particulate entering the home settles to the horizontal surfaces of the home before being picked up by any filter. The most effective benefit of air filtering is to protect the equipment conditioning the home.
All homes need a specific amont of fresh air ventilation when occupied. During cold windy weather most homes get enough fresh air. During calm warm weather, most home get little fresh air. As contractors and home occupants we need systems that will provide the amount of clean filtered fresh air blended and circulated throughout the home when occupied. Filtering could include the most extreme depending on the occupants needs. In addition maintain <50%RH throughout the space.
A ventilating whole house dehumidifier is one of the methods of doing this. Filtering levels can be custom designed to meet the needs of occupants. Using fresh make-up air ventilation has the added benefit of reducing infiltration of unfiltered air into the home. Also colthes driers, kitchen exhaust and bath fan need make-up air to function.
Fresh air and keep it dry are the basics. Then you can filter to your heart's content.