How large of a home is this. If your home is larger than 4000 sq. ft then I would definately look into VRF by Mitsubishi or Daikin. The advantage is very short duct runs, higher efficiencies, very quiet, no ductwork across roofs, variable capacities,etc. The only disadvantage is the initial cost and it takes a better technician to install and service.If you want something a little more high tech then you could go with Daikin Altherma, add radiant heating in the floor, solar on the roof, heat and cool the space and the domestic hot water.