Home is 2050 Sq. Ft. single story frame in Tampa, FL 33617. Replacing 16 yr old Lennox. Some modification to ductwork to increase flow to one side of L shape. I've obtained proposals from three contractors including the one who has been maintaining the system all that time. I am 74 with chronic coronary artery problems including surgery in 1998. More and more thinking air quality is vital. Wife is 72 in good health and both are retired. House is rarely empty.

System proposed(after much discussion):
Trane XL20i Heatpump
4TWZ0048, TAM7AOC48H41SA, BAYEVAC08LG1AA
Thermostat is listed as TCONT9000 but I think this is a typo and should be 900, find out tomorrow
Air Cleaner Honeywell TrueCLean

A) Overall how does this look?
B) What about the Trane CleanEffect air cleaner? I have a bias to matching components ex a good reason.
C) I don't need to run my house from afar with a thermostat but what about basic communication among components?

I have all these questions this weekend due to reading a number of threads here. I appreciate the knowledge shown.