With this type of setup, it would be possible to build a 'central plant in a box' type setup, that contained the controls, cold water supply and return, hot water supply and return, and a outdoor (or ground loop) coil supply and return. If gas is an option, it can be installed on the hot loop. In residential uses, I see no reason why you can't use the same loop for heating and domestic, as long as all components are domestic water rated. This type of box can include the pumps, chiller, etc. Accessories such as storage/buffer tanks, etc can be added, as can other items such as solar heat.
There's also no refrigerant work with a box like this. It's a self contained appliance, just like a refrigerator.