I'm not wild about having mini-splits -- too many filters to change, among other things. If we go with a VRF system, it would be with a traditional duct system and variable-speed AHU.
I've used these type units on several projects. The question is open because there is difficulty modeling their capabilities. Commercial load programs couldn't model how they take advantage of part load through compressor load matching also, the ratings system did not extend low enough to show their advantage as a heat pump in colder climates through the ability when optimized for heating to do heatpump operation down to 100% rated capacity at 0 degrees in some models without backup heat. The drawbacks are that by code you have to make provision for the smallest room with an interior unit to be able to handle a dumping of the entire refrigerant charge into the room should a catastrophic failure occur, the units do not handle outside air well without a separate dedicated system, and finding an installer with experience who can do all the refrigerant piping work required. They also need to have provision for condensate removal on a local level (at each indoor unit) and the units are in the room, hanging on a wall, up in a ceiling or standing by a wall. The good news is they are very quiet and if installed right are very efficient.
I like the dedicated whole house dehumidifier option for treating incoming OA. If it also connects to RA then it will help reduce the latent load on the AC.
Another option mentioned above in some of the other posts that I have used is the mini chiller system. On the surface these do not appear as efficient as say the VRF minisplits (they look identical by the way), but they can allow for greater diversity for greater possible equipment size reduction. Only water and maybe some glycol (not a very high concentration in your area, I imagine) run through the building so the refrigerant charge is all outdoors so that code restriction of accounting for refrigerant dumping goes away. Installation can be done more easily because it is water piping and not refrigerant, many more contractors can do that kind of installation as certification is less stringent. Well suited to new construction. Same other problems as VRF with condensate disposal. Worth looking into though.